A Bizarre Presentation of Bilateral Mandibular Osteoporotic Bone Marrow Defect (A Case Report)


  •   Abbas Al-Ramzi

  •   Maysoun Kasem

  •   Karim Ahmed


 BACKGROUND: Osteoporotic bone marrow defect of the jaw is an uncommon localized radiolucency that consists of hematopoietic red marrow with varying amounts of fatty yellow marrow. The lesion is usually asymptomatic and accidentally discovered during a routine radiographic examination; however, some studies showed different results.

CASE REPORT: This is an uncommon case of bilateral mandibular osteoporotic bone marrow defect in a 40-year- old healthy female. One of the defects reoccurred, and it involves dental implants.

PLAN OF TREATMENT: Lesion was managed by curettage and the patient was followed up after 1,6,12 months.

CONCLUSIONS: in order to diagnose FOBMD and differentiate it from other lesions, further researches are needed to help fully understand it, since the exact incident and etiology are not established yet. 

Keywords: bone marrow defect, hematopoietic origin, jaw radiolucency, mandible.


Schneider LC, Mesa ML, Fraenkel D. “Osteoporotic bone marrow defect: radiographic features and pathogenic factors”. Oral Surg Oral Med Oral Pathol 65:127Y129 1988.

Shafer WG, Hine MK, Levy BM. “A textbook of oral pathology”. 4th ed. Philadelphia: WB Saunders, Ch 10,544-5, 1983

Crawford BE, Weathers DR. “Osteoporotic marrow defects of the jaws”. J Oral Surg 1970; 28:600-3.

Barker BF, Jensen JL. Howell FV. “Focal osteoporotic bone marrow defects of the jaws”. Oral Surg 1974; 38:404-13

Shankland, II, W.E. and Bouquot, J.E. “Focal osteoporotic marrow defect: report of 100 new cases with ultrasonography scans”. CRANIO 2004; 22(4), pp.314-319.

Bouquot JE, Rohrer M, McMahon RE, Boc T. ”Focal osteoporotic marrow defect (FOMD) - literature review and report of 596 new cases”. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 94:211. 2002

Makek M, Lello G. “Focal osteoporotic bone marrow defects of the jaws”. J Oral Max fac Surg, 44:268-273, 1986

Lipani CS, Natiella JR, Greene WG. “The hematopoietic defect of the jaws: a report of sixteen cases”. J Oral Pathol, 11:411. 1982

Bravo-Calderón, D.M., Oliveira, D.T. and dos Santos, W.H.M. “Bilateral osteoporotic bone marrow defects of the mandible: a case report”. Head & face medicine. 8(1), p.22. 2012

Almeida, L.Y., Kato, R.B., Ribeiro, M.C. and León, J.E. “Focal osteoporotic bone marrow defect mimicking a mandibular cystic lesion”. Journal of Craniofacial Surgery, 25(4), pp.e324-e326. 2014

Sewell CMD, Almeida OP, Passeri LA. “Defeito osteoporótico-medula óssea”. Rev Assoc Paul Cir Dent. 44:321–323. 1990

Sanner JR, Ramin JE. “Osteoporotic, hematopoietic mandibular marrow defect: an osseous manifestation of sickle cell anemia”. J Oral Surg. 35:986–988. 1977

Garcia, N.G., Barros, F.B.A., Carvalho, M.M.D. and Oliveira, D.T. “Focal osteoporotic bone marrow defect involving dental implant: a case report”. International journal of implant dentistry. 1(1), p.18. 2015

Bayram B, Alaaddinoglu E. “Implant-box mandible: dislocation of an implant into the mandible”. J Oral Maxillofac Surg. 69:498–501. 2011

Sençimen M, Delilbasi C, Gülses A, Okçu KM, Gunhan O, Varol A. Focal osteoporotic hematopoietic bone marrow defect formation around a dental implant: a case report. Int J Oral Maxillofac Implants. 2011; 26:e1–4.

Gurevitch O, Slavin S, Resnick I, Khitrin S, Feldman A. “Mesenchymal progenitor cells in red and yellow bone marrow”. Folia Biol (Praha), 55:27–34. 2009

Lee BK, Choi SJ, Mack D, Oh SH. “Isolation of mesenchymal stem cells from the mandibular marrow aspirates”. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 112(6): e86-93, 2011


How to Cite
Al-Ramzi, A., Kasem, M., & Ahmed, K. (2020). A Bizarre Presentation of Bilateral Mandibular Osteoporotic Bone Marrow Defect (A Case Report). European Journal of Dental and Oral Health, 1(2). https://doi.org/10.24018/ejdent.2020.1.2.4