European Journal of Dental and Oral Health

Failure of Dental Implants and its Association with IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 Polymorphisms, Systematic Review, and Meta-Analysis of Clinical Trials

Alejandra Bono — 2025-03-25

The general objective of this work was to evaluate the IL-10 A/G rs1800896 and TNF-α G308A rs1800629308 polymorphisms with the loss of one or more dental implants through a systematic review and meta-analysis of clinical trials. The PRISMA guidelines established for systematic reviews and meta-analyses were followed. It was carried out on randomized controlled clinical trials, epidemiological studies obtained from the MEDLINE, EMBASE, LILACS, IBECS and Cochrane databases. The initial search returned 593 results. 28 articles were selected, and we excluded 12 studies that did not describe the genetic polymorphism we were looking for related to dental implant survival. Therefore, we included 4 articles in this review. We analyzed all these different categories of genes with their respective polymorphisms (IL-1A [-889], IL-1B [+3954], IL-1B [+3953], IL-1B [-511], IL-4 [+33 ], IL-4 [-590], IL-6 [-174], IL-10 [-1082], IL-10 [-819], IL-10 [-592], IL-1 receptor antagonist [IL-1ra]), tumor necrosis factor (TNF-α [-308]). There are very few comprehensive studies that have the same methodologies and similar data analyzes to be able to compare them that include the types of SNPs altered in the gene related to reduced implant survival to perform the meta-analysis. This systematic review confirms results that are still controversial due to the limited sample size, the definition in the terminology dental implant failure not yet defined equally in all studies, and the non-homogeneous inclusion and exclusion criteria, which include race, age, smoking, occlusion trauma, and periodontal disease.

Public Willingness to Participate in and Share Three-Dimensional (3D) Image Data from Orofacial Research: Results from a Preliminary Online Survey of Scottish Public Opinion

Mairead L. Bermingham — 2025-04-14

Background: Orofacial traits are influenced by a large number of loci; requiring large population-based studies for their detection. Public willingness to participate in and share three-dimensional (3D) image data from orofacial genetic research is essential to ensure feasible implementation of these studies. This preliminary study aims to explore the Scottish public’s willingness to participate in and share 3D image data from orofacial genetic research, providing baseline data for future research.

Methods: The online survey was administered from the 14th June–14th July 2017. Multinomial logistic regression was used to test for association with willingness to participate in and share image data from orofacial genetic research, with baseline demographics and prior knowledge of orofacial research as covariates.

Results: A total of 82 members of the Scottish public were recruited. The majority of respondents (83%) would participate in a research project that involves the collection of facial images. Of those who would participate, most (93%) would share their data outside of the UK. Fewer (3%) would only share their data within the UK. Education level and prior knowledge of the oral-systemic health relationship were associated with respondent’s willing ness to participate. Education level was also associated with respondent’s willingness to share image data.

Conclusions: This preliminary study indicates a high level of willingness among the Scottish public to participate in and share data from orofacial genetic research. The findings suggest that education level and prior knowledge of oral-systemic health influence participation, highlighting the need for targeted public engagement in orofacial genetic research. These results lay the groundwork for larger, more diverse studies to further explore these associations.

Various Benign and Pathological Lesions of Oral Cavity in Pediatric Patients

Sandhya J. Kadam — 2025-03-06

Oral soft tissue lesions in pediatric patients can be congenital or developmental. They can be asymptomatic and are observed during routine pediatrician or dentist examinations. Some of the lesions become symptomatic and present as an acute care visit. Initial examination and treatment of acute symptoms are done by a pediatrician, and a few of them may need referral to a dentist for definitive treatment such as removal of the lesion. Some lesions are more prevalent in patients of certain ethnicities, age groups, and sex of the patient. Treatment of oral lesions in pediatric patients differs as some lesions are self-limiting, regress spontaneously, and no treatment is needed. Lesions that recur and remain persistent need further investigation, such as a biopsy, followed by cytopathology and culture sensitivity tests. Oral lesions are usually limited to the oral cavity, but bigger lesions may spread locally and out of the oral cavity, involving lymph nodes. Soft tissue lesions can be of bacterial, viral, fungal, or unknown etiology. Identifying and treating these lesions may prevent the risk of systemic involvement and immunological responses. This article provides an overview of different benign and pathological oral conditions in pediatric patients, as well as their diagnoses and management. It highlights the importance of differentiating benign and complicated conditions to guide the specific treatments.

Trichomonas Tenax and Entamoeba Gingivalis Prevalence Among Palestinian Adults, A PCR-Based Cross-Sectional Study

Thikrayat Badrasawi — 2025-02-20

Introduction: Periodontal diseases affect the tissues responsible for tooth support within the oral cavity. These conditions are directly connected to tooth loss and other general health issues like cardiovascular diseases. Microorganisms associated with periodontal diseases have been extensively studied; however, parasites like T. tenax and E. gingivalis have been the least investigated and least frequently linked to periodontitis. This research aims to study the prevalence of these parasites in the Palestinian adult community.

Materials and Methods: A cross-sectional study was designed to reveal the prevalence of both parasites. Cities to be included in the study were selected via cluster sampling. 291 saliva and plaque scraping samples were extracted from subjects who were eligible and accepted to enroll. Deoxyribonucleic acid (DNA) extraction was done, followed by Polymerase chain reaction (PCR) and agarose gel electrophoresis to detect parasite infection.

Results: After conducting DNA extraction and PCR, all samples were negative for T. tenax and E. gingivalis infection.

Conclusion: The negative results of this study were insufficient to establish the prevalence of the two parasites among Palestinian adults. Improved general and oral health may have reduced parasite prevalence. Further research is needed to identify other potential microorganisms directly linked to these oral diseases.

A Review of Platelet-Rich Fibrin Uses in Oral Surgery and Dental Implantology

Noor Mohammed Al-Noori — 2025-02-03

Platelet-rich fibrin is a healing biomaterial that can be used unaccompanied or in conjunction with bone grafts to promote hemostasis, bone development, and maturation. It has a tremendous likelihood for bone and soft tissue redevelopment and does not cause any inflammatory reactions. The platelet-rich Fibrin preparation protocol is very simple: Collection of blood in the glass tube and then directly centrifuging it without any additives, establishing fixed fibrin clots rich in platelet leucocytes and growth factors set in the fibrin. Platelet-rich fibrin advantages: it does not dissolve rapidly and is prepared at a low cost. Platelet-rich fibrin is used in almost all oral surgery and dental implant procedures because of its effect on the healing of both hard and soft tissue of the oral cavity.