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The holistic dentistry is one of the oldest biological forms of dentistry which highlights the importance of oral health and its impact on the overall health of the patient. It roots deeply in prevention of causative factor of diseases instead of treating it using potentially toxic materials. Holistic approach is helpful in children with congenital developmental disorders as such patients have restrictions that are physical or mental which leads to deterioration in self-care, and oral care state. Potocki Lupski syndrome is one such syndrome where the child presents feature of infantile hypotonia, sleep disorder, congenital anomalies of the cardiovascular system, poor oral motor skills and crowded dentition that leads to failure to thrive. In this report, we present a case of a 4-year-old child with Potocki Lupski syndrome who was intervened though a holistic dentistry using a multidisciplinary approach.

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