Oral Lichen Planus Genetics Update



Abstract Views
0

Downloads
0

Citations

Share

##plugins.themes.bootstrap3.article.sidebar##

Submitted Jun 26, 2022
Published Aug 29, 2022
10.24018/ejdent.2022.3.4.205

Abstract viewed = 0 times

Table of Contents

##plugins.themes.bootstrap3.article.main##

Lichen planus is a chronic autoimmune multi-factorial inflammatory condition of the mucocutaneous skin that mainly interests the skin and oral mucosa. Oral Lichen Planus (OLP) affects 0.5 to 1% of the world's population and all human races equally. The factors that act as triggers of autoimmune processes and determine the appearance of OLP are represented by genetic predisposition, skin injuries, viral infections, contact allergies, and medications. OLP affects the oral mucosa and occurs frequently on the inside of the cheeks and less often on the edges of the tongue, gums, or lips. The condition is manifested by the appearance of painful erosions and mouth ulcers, accompanied by erythema and gingival scaling, and sometimes localized inflammation of the gums, near the amalgam fillings. There are 132 genes currently involved in the etiopathogenesis of OLP, but only a few appear to play a major role. These genes have been termed "leader genes". Thus, based on bioinformatics studies, the main genes involved in the pathogenesis of OPL are JUN, EGFR, FOS, IL2, and ITGB4.  Although genetic status, immune system background, and infectious diseases are considered to be the most important incriminating and determining factors, the etiopathogenesis of OLP remains poorly known. Further genetic research is needed in order to achieve the generalizability of the findings and to strengthen the obtaining results.

Keywords: Oral Lichen Planus, genetic predisposition, "leader genes"

References

  1. Gupta S, Jawanda MK. Oral Lichen Planus: An Update on Etiology, Pathogenesis, Clinical Presentation, Diagnosis and Management. Indian J Dermatol. 2015; 60(3): 222-229.
     Google Scholar
  2. Gorouhi F, Davari P, Fazel N. Cutaneous and mucosal lichen planus: a comprehensive review of clinical subtypes, risk factors, diagnosis, and prognosis. Scientific World Journal. 2014; 2014: 742826.
     Google Scholar
  3. Villa TG, Sánchez-Pérez Á, Sieiro C. Oral lichen planus: a microbiologist point of view. Int Microbiol. 2021; 24: 275-289.
     Google Scholar
  4. Lauritano D, Arrica M, Lucchese A, Valente M, Pannone G, Lajolo C, et al. Oral lichen planus clinical characteristics in Italian patients: a retrospective analysis. Head Face Med. 2016; 12: 18.
     Google Scholar
  5. Zotti F, Nocini R, Capocasale G, Bertossi D, Fior A, Peretti M, et al. Oral Lichen Planus: risk factors of malignant transformation and follow up. Ten years retrospective study. J Clin Exp Dent. 2021; 13(7): e630-e636.
     Google Scholar
  6. Raj G, Raj M. Oral Lichen Planus. [Internet] 2022. [Updated 2022 Feb 11]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK578201/
     Google Scholar
  7. Mortazavi H, Safi Y, Baharvand M, Rahmani S. Diagnostic Features of Common Oral Ulcerative Lesions: An Updated Decision Tree. Int J Dent. 2016; 2016: 7278925.
     Google Scholar
  8. Lomaga MA, Polak S, Grushka M, Walsh S. Results of patch testing in patients diagnosed with oral lichen planus. J Cutan Med Surg. 2009; 13(2): 88-95.
     Google Scholar
  9. Wang W, Wang M, Ahmed MMS, Zhao Y, Wu H, Musa M, et al. FAM3B Serves as a Biomarker for the Development and Malignancy of Oral Lichen Planus. Int J Gen Med. 2022; 15: 763-776.
     Google Scholar
  10. Chauhan I, Beena VT, Srinivas L, Sathyan S, Banerjee M. Association of cytokine gene polymorphisms with oral lichen planus in Malayalam-speaking ethnicity from South India (Kerala). J Interferon Cytokine Res. 2013; 33(8): 420-427.
     Google Scholar
  11. Akhoondzadeh Haqiqi M, Pourmoshir N, Hosseini Bereshneh A. Clinical and Genetic Aspects of Oral Lichen Planus. Int J of Biomed Adv Res. 2016; 7(6): 251-256.
     Google Scholar
  12. Wieduwilt MJ, Moasser MM. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol Life Sci. 2008; 65(10): 1566-1584.
     Google Scholar
  13. Anon, Fos fos proto-oncogene, AP-1 transcription factor subunit - NIH genetic testing registry (GTR) - NCBI. National Center for Biotechnology Information. [Internet] [cited 2022 June 10] Available from: https://www.ncbi.nlm.nih.gov/gtr/genes/2353/
     Google Scholar
  14. Anon, OMIM entry - * 147557 - integrin, beta-4; ITGB4. [Internet] [cited 2022 June 9] Available from: https://www.omim.org/entry/147557
     Google Scholar
  15. Sirajudeen S, Shah I, Al Menhali A. A Narrative Role of Vitamin D and Its Receptor: With Current Evidence on the Gastric Tissues. Int J Mol Sci. 2019; 20(15): 3832.
     Google Scholar
  16. Shen H, Liu Q, Huang P, Fan H, Zang F, Liu M, et al. Vitamin D receptor genetic polymorphisms are associated with oral lichen planus susceptibility in a Chinese Han population. BMC Oral Health. 2020; 20(1): 26.
     Google Scholar
  17. Idris A, Ghazali NB, Koh D. Interleukin 1β-A Potential Salivary Biomarker for Cancer Progression? Biomark Cancer. 2015; 7: 25-29.
     Google Scholar
  18. Xu XH, Liu Y, Feng L, Yang YS, Liu SG, Guo W, et al. Interleukin-6 released by oral lichen planus myofibroblasts promotes angiogenesis. Exp Ther Med. 2021; 21(4): 291.
     Google Scholar
  19. Akmalova GM, Chuykin SV, Ron GI, Chernysheva ND, Galimova ES, Gilyazova IR, et al. Genetic markers of predisposition to oral lichen planus recurrence development. Kazan Medical Journal. 2016; 97(3): 381-387.
     Google Scholar
  20. Zhou Y, Vieira AR. Association between TNFα - 308 G/A polymorphism and oral lichen planus (OLP): a meta-analysis. J Appl Oral Sci. 2018; 26: e20170184.
     Google Scholar
  21. En.wikipedia.org. Interferon gamma - Wikipedia. [Internet] 2022. [cited 2022 June 12] Available from: https://en.wikipedia.org/wiki/Interferon_gamma
     Google Scholar
  22. Al-Mohaya MA, Al-Otaibi L, Al-Harthi F, Al Bakr E, Arfin M, Al-Asmari A. Association of genetic polymorphisms in interferon-γ, interleukin-6 and transforming growth factor-β1 gene with oral lichen planus susceptibility. BMC Oral Health. 2016; 16(1): 76.
     Google Scholar
  23. Tan Y-Q, Zhang J, Du G-F, Lu R, Chen G-Y, Zhou G. Altered Autophagy-Associated Genes Expression in T Cells of Oral Lichen Planus Correlated with Clinical Features. Mediators Inflamm. 2016; 2016: 4867368.
     Google Scholar
  24. Xie F, Gleue CA, Deschaine M, Dasari S, Lau JS, Sartori-Valinotti JC, et al. Whole-exome sequencing of transforming oral lichen planus reveals mutations in DNA damage repair and apoptosis pathway genes. J Oral Pathol Med. 2022; 51(4): 395-404.
     Google Scholar
  25. Pakfetrat A, Delavarian Z, Mohtasham N, Mohajer Tehran F, Samiee N. Cathepsin-B and caveolin-1 gene expressions in oral lichen planus and oral squamous cell carcinoma. Mol Biol Rep. 2022; 49(4): 2945-2951.
     Google Scholar
  26. Enășescu DA, Moisescu MG, Imre M, Greabu M, Ripszky Totan A, Stanescu-Spinu I, et al. Lutein Treatment Effects on the Redox Status and Metalloproteinase-9 (MMP-9) in Oral Cancer Squamous Cells-Are There Therapeutical Hopes? Materials (Basel). 2021; 14(11): 2968.
     Google Scholar
  27. Albu ŞD, Pavlovici RC, Imre M, Ion G, Ţâncu AMC, Albu CC. Phenotypic heterogeneity of non-syndromic supernumerary teeth: genetic study. Rom J Morphol Embryol. 2020; 61(3): 853-861.
     Google Scholar
  28. Russu EA, Mihai MM, Russu LE, Russu MG, Bencze MA, Albu SD, et al. Alopecia areata: Impressive results using low-level laser therapy. World Journal of Advanced Research and Reviews. 2022; 14(03): 11-15.
     Google Scholar
  29. Albu CC, Pavlovici RC, Imre M, Ţâncu AMC, Stanciu IA, Vasilache A, et al.. Research algorithm for the detection of genetic patterns and phenotypic variety of non-syndromic dental agenesis. Rom J Morphol Embryol. 2021; 62(1): 53-62.
     Google Scholar
  30. Wang Z, Yao H, Cui B, Ning G, Tang GY. Genetic linkage analysis of oral lichen planus in a Chinese family. Genet Mol Res. 2011; 10(3): 1427-1433.
     Google Scholar


Most read articles by the same author(s)

Obs.: This plugin requires at least one statistics/report plugin to be enabled. If your statistics plugins provide more than one metric then please also select a main metric on the admin's site settings page and/or on the journal manager's settings pages.