Lipomas are the most frequent benign neoplasms of mesenchymal origin, and they mostly occur in various anatomical sites, including the palate, lip, buccal mucosa and vestibule, tongue, and floor of the mouth. Lipomas have a low incidence between 1 to 4% of benign oral cavity lesions. The clinical presentation of lipomas is generally characterized as a neoformation with well-demarcated borders. In this clinical case report, a 66-year-old female patient presented with pain and an inflamed region in the oral cavity. In intraoral clinical examination, a neoformation of 1 centimeter in diameter was observed and located in the jugal mucosa of the right side of the oral cavity. Furthermore, an excisional biopsy was chosen as the treatment method, and a postoperative histopathological study was conducted. Surgical excision is the treatment of choice for preventing recurrence in patients with oral lipomas.
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